The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors.
The rise of multidrug-resistant and totally drug-resistant tuberculosis and the association with an increasing number of HIV-positive patients developing tuberculosis emphasize the necessity to find new antitubercular targets and drugs. The antigen 85 (Ag85) complex from Mycobacterium tuberculosis plays important roles in the biosynthesis of major components of the mycobacterial cell envelope. ...
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The increasing prevalence of drug-resistant tuberculosis highlights the need for identifying new antitubercular drugs that can treat these infections. The antigen 85 (Ag85) complex has emerged as an intriguing mycobacterial drug target due to its central role in synthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane. Here we identify ebselen (EBS) as a...
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متن کاملPurification and immunoreactivity of three components from the 30/32-kilodalton antigen 85 complex in Mycobacterium tuberculosis.
The three proteins of the antigen 85 complex (85A, 85B, and 85C), which are major secretory products of Mycobacterium tuberculosis, were purified to homogeneity in large amounts by a combination of chromatography on hydroxylapatite, DEAE-Sepharose, and DEAE-Sephacel and gel filtration from M. tuberculosis culture filtrate. Then we examined the immunological reactivity of the three proteins in t...
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and genomic organization of the gene coding gene family: cloning, sequence determination, Mycobacterium bovis BCG are members of a of Mycobacterium tuberculosis and The genes coding for the antigen 85 complexes A gene encoding the 33-kDa secreted protein of Mycobacterium tuberculosis (antigen 85-C) was isolated and sequenced. The corresponding DNA sequence contains a 1,020-bp coding region. The...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1992
ISSN: 0146-0749
DOI: 10.1128/mr.56.4.648-661.1992